1st Edition
Zebrafish Models of Neurodegenerative Disorders
Advancing our understanding of neurodegenerative diseases demands innovative tools and approaches. Zebrafish Models in Neurodegenerative Disorders offers a comprehensive examination of zebrafish as a translational model for studying the molecular and cellular mechanisms of diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Beginning with the first section informing about the basic molecular mechanisms of neurodegenerative disorders, biomarkers, and therapeutic approaches, the book continues with the detailed exploration of zebrafish physiology, genetics, and behavioural phenotypes as they pertain to neurodegenerative pathologies; insight into cutting-edge technologies, including CRISPR/Cas9 genome editing; and in-depth analysis of zebrafish models, highlighting their strengths in modelling disease progression and therapeutic testing.
Section I: Molecular Mechanisms, Markers and Pharmacotherapy of Neurodegenerative Disorders.
Chapter 1: Main Molecular Mechanisms of Neurodegenerative Disorders.
Erdinç Dursun & Duygu Gezen-Ak
Chapter 2: Molecular Markers of Neurodegenerative Disorders.
Elif Ozkok
Chapter 3: Pharmacotherapy of Neurodegenerative Diseases.
Nurdan Tekin, Yekta Çulpan & Rezzan Gülhan
Section II: Zebrafish Model Organism to Study Neurodegenerative Disorders.
Chapter 4: Zebrafish Model of Neurodegenerative Disorders.
Nitasha Rana, Palak Ahuja, Charan Singh and Arti Singh
Chapter 5: Zebrafish as a Model Organism for the Investigation of Neurodegenerative Aspects of Autism Spectrum Disorders.
Gizem Eğilmeze and Ebru Emekli-Alturfan.
Chapter 6: Neurogenesis in the Zebrafish Olfactory Epithelium in Response to Nuerotoxicity and Injury.
Yigit Kocagöz and Stefan H. Fuss.
Chapter 7: Epigenetic Regulations during Neurogenesis in Zebrafish.
Samudra Gupta, Aoishik Roy and Subhra Prakash Hui.
Chapter 8: Proteomic Approaches on Neurodegenerative Disease Models in Zebrafish.
Mustafa Gani Sürmen and Saime Sürmen.
Chapter 9: Zebrafish as a Model for Functional Analyses of Alzheimer's Disease-Related Genes and Drug Development.
Caghan Kizil.
Chapter 10: Perfluorinated Chemicals, Zebrafish, and Neurodegenerative Disorders.
Emma Ivantsova and Christopher J. Martyniuk.
Chapter 11: Effect of Myelination of Neurodegeneration and Neurodegenerative Diseases in the Zebrafish Model.
Efruz İrem Akkuş-Yaylamış and Müjgan Cengiz.
Chapter 12: Zebrafish as a Model Organism to Evaluate the Neurotoxic Effects of Endocrine Disruptive Chemicals.
Merih Beler and Ebru Emekli-Alturfan.
Chapter 13: Using Zebrafish to Explore the Brain-Gut Axis in Neurodegenerative Disorders.
İsmail Ünal.
Chapter 14: Glyphosate Exposure and Neurological Outcomes in Zebrafish.
Ana Gomes, Sandra M. Monteiro, Carlos Venâncio and Luís Félix.
Chapter 15: Zebrafish Model Organism to Investigate Pain in Neurodegenerative Diseases.
Derya Cansiz.
Chapter 16: Neurodegenerative Disease Modelling with CRISPR/CAS Systems in Zebrafish.
Barış Çerçi, Fulya Yaylacıoğlu Tuncay and Pervin Rukiye Dinçer.
Chapter 17: Zebrafish Genetic Models of Alzheimer's Disease.
Goksu Kasarci Kavsara, Baris Ertugrul, Sinem Bireller and Bedia Cakmakoglu.
Chapter 18: Neurodegenerative Effects of Boron and Other Elements on Zebrafish and Zebrafish Embryos.
A. Begüm Özel-Korlu and Ayşen Yarat.
Chapter 19: Effects of Microplastics and Nano-plastics on Neurodevelopment and Neurodegeneration in Zebrafish.
Zülal Mızrak, Derya Cansız and Ebru Emekli-Alturfan.
Chapter 20: Investigation of the Effects of Vitamins on Neurodegenerative Diseases using Zebrafish as a Model Organism.
Semanur Işıkoğlu, İsmail Ünal and Ebru Emekli-Alturfan.
Chapter 21: Usability of Zebrafish as a Model Organism to Investigate the Relationship between Breast Milk and Neurodegeneration.
Tuğba Tunalı-Akbay.
Chapter 22: Antimicrobial Agents in Mouthwashes: Unveiling Neurotoxic and Neurodegenerative Impacts through Zebrafish Models.
Atakan Karagöz and Ebru Emekli-Alturfan
Biography
Dr. Ebru Emekli-Alturfan received her PhD in biochemistry from the University of Marmara in 2006 and was appointed as a professor in the Faculty of Dentistry at Marmara University, specifically within the Department of Basic Medical Sciences in 2016. Ebru Emekli-Alturfan leads a research group using Zebrafish as a model organism to investigate molecular mechanisms of neurodegeneration. Their research encompasses neurodegeneration, neurodevelopment, and its molecular regulation in vertebrate development. They use zebrafish as a main model system. To investigate the genetic foundation of human diseases, they work together with colleagues both within the Medical and Dental School and internationally to develop and implement in vivo models. Besides leading a research group, Ebru Emekli-Alturfan teaches medical biochemistry courses at Marmara University's Faculty of Dentistry and Institute of Health Sciences.
